High Throughput Screening (HTS) system Compatible with standard well plate configurations
High Throughput Screening (HTS) system Compatible with standard well plate configurations

THz-Raman® Well-Plate System (WPS)

Coherent’s new TR-WPS Automated Well-plate Measurement System combines high throughput screening (HTS) capability with our patented low-frequency/THz-Raman® technology to automatically capture the entire Raman spectrum from -800 cm-1 to +2800 cm-1 for common well-plate measurements. Ideal for screening and identification of polymorphic compounds and co-crystals, or quantifying degree of crystallinity in pharmaceuticals, THz-Raman delivers fast, sensitive, and reliable measurements of both chemical composition and molecular structure. The relative ease of sample handling and measurement ensures that the user spends more time with the data, rather than collecting it.

THZ-Raman Spectroscopy Well-Plate System

for Advanced Materials Characterization

Parameter Value
Laser Wavelength 785 nm
Laser Power Up to 400 mW at sample
Spectral Range -800 cm-1 to 2800 cm-1
Spectral Dispersion 2 cm-1 per pixel
Focusing Manual or Auto
Objectives 4 user definable (e.g. 5x, 10x, 20x)
Maximum Sample Size 125 mm x 85 mm (fits standard well plate)
Power/Voltage 110-240 VAC ± 10%, 300 W Maximum
Dimensions 950 mm (W) x 650 mm (D) x 415 mm (H)
Weight 50 kg
Laser Class Class 1 Laser. Complied with IEC60825-1

The TR-WPS has been designed to be fully automated, from sample insertion to data generation. The sample is excited with a 785 nm Coherent CleanLine™ laser from below the well in an inverted microscope format. A plate autofocusing system ensures measurement repeatability, and an integrated vision system with polarized light detection can be used to determine areas of interest within each well.

The WPSTM Application Software Interface has a highly intuitive GUI with a layered design, enabling fast learning and simplified operation, while providing extensive additional functionality in advanced mode.

Features & Benefits


  • Fully automated operation
  • Collects both Stokes and anti-Stokes signals from -800 to +2800 cm-1 with ~4 cm-1 spectral resolution substrates
  • Configurable scanning patterns
  • FloodLightMode to enhance collection speed and averaging performance
  • Intra-well mapping data collection
  • Plate autofocusing system
  • Automated calibration
  • Polarized Light Detection
  • SPC and ASCII File Formats
  • User-definable file descriptors
  • Save and recall experiment parameter configurations
  • Compatible with standard 6, 12, 24, 48, 96, 384, or 1536 well plates, as well as custom
  • Advanced Mode enables user-definable patterns and sampling routines

Related Materials

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